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KMID : 0370020030170000061
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Chung-Ang Journal of Pharmacal Sciences
2003 Volume.17 No. 0 p.61 ~ p.66
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Effects of Patchouli Essential Oils on Melanin Production
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Abstract
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To investigate effects of patchouli essential oils on whitening activity, we measured their effect on anti-oxidant activity, tyrosinase activity and MSH-induced melanin production. In DPPH radical scavenging activity, patchouli significantly removed DPPH radical, suggesting that patchouli has anti-oxidant activity. Patchouli inhibited both purified-tyrosinase activity and MSH-stimulated melanin production in B16 melanoma cells in a dose-dependent manner. From the above results, such an inhibitory effect of patchouli may be due to the inhibition of tyrosinase associated with anti-oxidant activity, which suggest that patchouli essential oils appear to be materials to develope whitening agents.
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